A/Prof Craig Jenne
Canada Research Chair in Imaging Approaches Towards Studying Infection
Department of Microbiology, Immunology & Infectious Diseases (MIID)
Department of Critical Care Medicine
Director, Snyder Translational Lab in Critical Care Medicine
Please contact firstname.lastname@example.org to schedule a meeting with Craig.
Imaging Infection, Inflammation, and Coagulation
Our work focuses on the use of the cutting-edge technique known as intravital microscopy to study the immune response to bacterial and viral infection. Intravital microscopy allows us to look into the tissues of a live animal and “see” individual immune cells within the blood vessels and tissues. By watching the immune response we are able to directly see which immune cells interact with the tissues such as the lung and liver, and we can visualize the resulting tissue damage. Additionally, we have developed brand new markers that can be used with an intravital microscope to see and measure blood-clotting in real-time. With this approach we can directly address the question about whether infection-induced inflammation leads to the development of small blood clots that cause damage to blood vessels and tissues. Our recent findings point to a clear collaboration between the coagulation cascade and the host immune response that both enhances immunity, but also dramatically increases collateral tissue damage. By understanding these linkages, we aim to functionally uncouple coagulopathy from immunity, preserving the host’s ability to respond to, and clear, an infection while limiting collateral tissue damage and improving patient outcomes.
Dr. Craig Jenne started his research career as a graduate student at the University of Calgary under the supervision of Dr. John Reynolds. Following his PhD, Dr. Jenne joined an NIH collaboration between the University of California San Francisco and the Australian National University. During this time, under the mentorship of Dr. Jason Cyster and Dr. Chris Goodnow, an interest in the interface between innate and adaptive immunity was peeked.
Dr. Jenne returned to Calgary to join the group of Dr. Paul Kubes. Here Dr. Jenne was exposed to the field of intravital microscopy, an area that now has become his primary focus. During his time in Dr. Kubes’ lab, Dr. Jenne has developed a number of models to study the innate immune response to viral and highly pathogenic bacterial infections. It was also during this time that Dr. Jenne took on the role of Scientific Director of the Snyder Translational Lab in Critical Care Medicine, a position that allows him to work directly with Clinicians and Researchers on human clinical studies.
Dr. Jenne has a faculty appointment within the Department of Microbiology, Immunology and Infectious Diseases and the Department of Critical Care Medicine at the University of Calgary and is continuing his work using intravital microscopy to study the early innate immune response to viral and bacterial infections.
A light lunch is served prior to the seminar at 11:45am in the seminar room foyer, level 2, TRF Building.
Further information, including the link to add the seminar series to your google calendar, is available from CID Weekly Seminar Series website [http://www.med.monash.edu.au/scs/medicine/cid/seminar-series.html]